| P | Name | B/T | BA | HR | RBI | Player Note |
| C | Greg Dini | R/R | .296 | 6 | 50 | 2nd-Team All-Conference USA selection |
| 1B | Micah Owings | R/R | .359 | 18 | 63 | Conference USA Player of the Year |
| or | Scott Madden | R/R | .356 | 4 | 47 | Lone holdover from the 2001 CWS team |
| 2B | Joe Holland | R/R | .293 | 6 | 31 | One of five seniors on 2005 roster |
| or | Cat Everett | S/R | .250 | 0 | 4 | Played in 42 games, including 14 starts |
| 3B | Brad Emaus | R/R | .327 | 13 | 56 | Conference USA Freshman of the Year |
| SS | Tommy Manzella | R/R | .351 | 8 | 62 | 1st-Team All-Confernece USA selection |
| LF | Matt Barket | R/R | .279 | 6 | 46 | Team captain; ranks sixth on team in RBI |
| or | Mark Hamilton | L/L | .322 | 10 | 44 | 2005 New Orleans Regional MVP |
| CF | Nathan Southard | R/R | .353 | 12 | 53 | 1st Team All C-USA/C-USA Tourney |
| RF | Brian Bogusevic | L/L | .323 | 0 | 24 | Semifinalist for several national awards |
| or | Matt Barket | R/R | .279 | 6 | 46 | Will likely play right when Bogusevic pitches |
| DH | Scott Madden | R/R | .356 | 4 | 47 | Has seen time at first, catcher and DH |
| or | Micah Owings | R/R | .359 | 18 | 63 | Will likely hit for himself when pitching |
